Stop Aging Solutions

Spring Fever: Season's Picks for Longevity

Sun, 20 May 2012 05:00:46 +0000

As spring fever gives way to rising temperatures, nature’s new blooms and crops fill our markets with an abundance of seasonal produce.

Source:Spring Fever: Season's Picks for Longevity

A Brief Layperson's Tour of the Philosophy of Nonexistence

Sun, 20 May 2012 05:00:04 +0000

It is taken as a tenet around here that involuntary death is a bad thing, and the process of getting to be dead despite your own wishes on the matter is arguably worse - it involves a great deal of ongoing suffering and pain as the body progressively fails. Greatly diminishing the incidence of death is one aim of the longevity science movement, achieved through the elimination of degenerative aging, the greatest cause of death. Can we say why being dead is bad, however? That is supposedly a harder job than declaring suffering to be bad and worthy of amelioration…

Source:A Brief Layperson's Tour of the Philosophy of Nonexistence

An Aubrey de Grey Video AMA Gathering Questions at Reddit

Sat, 19 May 2012 05:00:23 +0000

One of the many popular and distinct online communities that make up Reddit is IAmA (”I am a”), which runs verified question and answer sessions (AMAs, or “ask me anything”) with all sorts of folk in interesting positions, with interesting jobs, or who are just plain interesting. You might consider it the crowdsourced, irreverent, collaborative offspring of chat shows, radio call-in programs, and the last ten years of online bulletin board evolution - this is what the kids do nowadays in place of turning on the TV or radio. In any case, I somehow entirely missed noting that a video…

Source:An Aubrey de Grey Video AMA Gathering Questions at Reddit

Old Calorie Restricted Rats Act Younger Than Their Peers

Sat, 19 May 2012 05:00:07 +0000

No great surprise here, given that calorie restriction in mammals slows almost all measures of aging investigated to date: “Long-term caloric restriction (CR) has been reported to extend the life spans, delay the onset and decrease the incidence of a broad spectrum of age-associated diseases. However, its effect on rat explorative behaviour is still unclear. In the present study, a number of behavioural measures were continuously monitored in 3-, 12-, 24-25-, 28-29- and 35-44-month-old male Wistar rats that were fed either ad libitum or placed on a caloric restricted diet. A gradual decline in locomotor activity of the ad libitum…

Source:Old Calorie Restricted Rats Act Younger Than Their Peers

Arguing a Role for the Hypothalamus in Aging

Fri, 18 May 2012 05:00:52 +0000

Researchers here analyze the proteome of the hypothalamus and argue for an important role in coordinating bodily responses to ongoing changes caused by aging: “The aging process affects every tissue in the body and represents one of the most complicated and highly integrated inevitable physiological entities. The maintenance of good health during the aging process likely relies upon the coherent regulation of hormonal and neuronal communication between the central nervous system and the periphery. Evidence has demonstrated that the optimal regulation of energy usage in both these systems facilitates healthy aging. However, the proteomic effects of aging in regions of…

Source:Arguing a Role for the Hypothalamus in Aging

The Maintenance Gap

Fri, 18 May 2012 05:00:23 +0000

Much of the mainstream aging research community has little interest in building therapies for aging, being focused on investigation only - though, fortunately, this situation is changing rapidly these days. The past stigma associated with public discussion of treating and ultimately preventing aging has largely evaporated within the scientific world. Among those researchers who are interested in therapies for aging, most are focused on the slow boat of metabolic alteration: work that will have comparatively little pay-off even if successful, but which fits more readily into established research programs and the prejudices of research funding institutions. The principal downside of…

Source:The Maintenance Gap

Investigating the Association of ApoE4 with Alzheimer's

Fri, 18 May 2012 05:00:07 +0000

Researchers continue to investigate why the ApoE4 gene variant is associated with Alzheimer’s disease: “A well-known genetic risk factor for Alzheimer’s disease triggers a cascade of signaling that ultimately results in leaky blood vessels in the brain, allowing toxic substances to pour into brain tissue in large amounts, scientists report … a gene called ApoE4 makes people more prone to developing Alzheimer’s. People who carry two copies of the gene have roughly eight to 10 times the risk of getting Alzheimer’s disease than people who do not. [Scientists] found that ApoE4 works through cyclophilin A, a well-known bad actor in…

Source:Investigating the Association of ApoE4 with Alzheimer's

Spring Fever: Season's Picks for Longevity

Thu, 17 May 2012 05:01:06 +0000

As spring fever gives way to rising temperatures, nature’s new blooms and crops fill our markets with an abundance of seasonal produce.

Source:Spring Fever: Season's Picks for Longevity

A Popular Press Article on Longevity Science

Thu, 17 May 2012 05:00:41 +0000

The media and public at large have been trained to think of medicine, and especially longevity-related medicine, in terms of pills - things you can consume, colorful drug capsules produced in the old-style fashion by Big Pharma. This is somewhat ridiculous, and leads to a focus on the entirely the wrong branches of research, those unlikely to deliver meaningful healthy life extension. The future of rejuvenation biotechnology involves gene therapies, infusions of bacterial enzymes, and so forth; for the foreseeable future little of that will be stuff that you stick into your mouth. Calling these medicines drugs rather than procedures…

Resilient Biochemistry in Naked-Mole Rats

Thu, 17 May 2012 05:00:23 +0000

Naked mole-rats are becoming very well studied. Researchers are attempting to find the root causes of cancer immunity and exceptional longevity in this species, with an eye to creating beneficial medical biotechnologies for humans. Fight Aging! has seen a couple of items on naked mole-rats already this month, which is illustrative of the present pace: More on NRG-1 in Naked Mole-Rats Enhanced Proteasome Activity in Naked Mole Rats Present theories are varied, but on the longevity side of the house the consensus appears to lean towards an increased resistance to forms of cellular membrane damage - naked mole rat membranes…

Source:Resilient Biochemistry in Naked-Mole Rats